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TitleMetal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis.
Journal, issue, pagesMol. Pharmacol., Vol. 96, Page 580-588, Year 2019
Publish dateMar 24, 2019 (structure data deposition date)
AuthorsLisnyansky, M. / Yariv, E. / Segal, O. / Marom, M. / Loewenstein, A. / Ben-Tal, N. / Giladi, M. / Haitin, Y.
External linksMol. Pharmacol. / PubMed:31427399
MethodsX-ray diffraction
Resolution2.202 Å
Structure data

PDB-6r4v:
Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate
Method: X-RAY DIFFRACTION / Resolution: 2.202 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-BFQ:
IBANDRONATE / medication*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Bisphosphonate / ibandronate / geranylgeranyl diphosphate / prenyltransferase

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