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-Structure paper
| Title | Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. |
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| Journal, issue, pages | J. Med. Chem., Vol. 62, Page 7769-7787, Year 2019 |
| Publish date | Mar 28, 2019 (structure data deposition date) |
 Authors | Munck Af Rosenschold, M. / Johannesson, P. / Nikitidis, A. / Tyrchan, C. / Chang, H.F. / Ronn, R. / Chapman, D. / Ullah, V. / Nikitidis, G. / Glader, P. ...Munck Af Rosenschold, M. / Johannesson, P. / Nikitidis, A. / Tyrchan, C. / Chang, H.F. / Ronn, R. / Chapman, D. / Ullah, V. / Nikitidis, G. / Glader, P. / Kack, H. / Bonn, B. / Wagberg, F. / Bjorkstrand, E. / Andersson, U. / Swedin, L. / Rohman, M. / Andreasson, T. / Bergstrom, E.L. / Jiang, F. / Zhou, X.H. / Lundqvist, A.J. / Malmberg, A. / Ek, M. / Gordon, E. / Pettersen, A. / Ripa, L. / Davis, A.M. |
 External links | J. Med. Chem. / PubMed:31415176 |
| Methods | X-ray diffraction |
| Resolution | 2.35 Å |
| Structure data |  PDB-6r7d: |
| Chemicals |  ChemComp-JUQ:  ChemComp-NI:  ChemComp-PLM:  ChemComp-LMT:  ChemComp-HOH: |
| Source |
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 Keywords | MEMBRANE PROTEIN / Inhibitor / arachidonic acid cascade / cysteinyl leukotrienes |
homo sapiens (human)