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TitleTargeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling.
Journal, issue, pagesCell Chem Biol, Vol. 26, Page 1417-1426.e5, Year 2019
Publish dateFeb 14, 2018 (structure data deposition date)
AuthorsJiang, C. / Tang, Y. / Ding, L. / Tan, R. / Li, X. / Lu, J. / Jiang, J. / Cui, Z. / Tang, Z. / Li, W. ...Jiang, C. / Tang, Y. / Ding, L. / Tan, R. / Li, X. / Lu, J. / Jiang, J. / Cui, Z. / Tang, Z. / Li, W. / Cao, Z. / Schneider-Poetsch, T. / Jiang, W. / Luo, C. / Ding, Y. / Liu, J. / Dang, Y.
External linksCell Chem Biol / PubMed:31402318
MethodsX-ray diffraction
Resolution1.30860259206 Å
Structure data

PDB-5zbz:
Crystal structure of the DEAD domain of Human eIF4A with sanguinarine
Method: X-RAY DIFFRACTION / Resolution: 1.30860259206 Å

Chemicals

ChemComp-SAU:
13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium / alkaloid*YM

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / eukaryotic translation initiation factor 4A / sanguinarine / inhibitor / TRANSLATION

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