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Structure paper

TitleStructure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 16829-16834, Year 2019
Publish dateDec 20, 2018 (structure data deposition date)
AuthorsTilegenova, C. / Cortes, D.M. / Jahovic, N. / Hardy, E. / Hariharan, P. / Guan, L. / Cuello, L.G.
External linksProc. Natl. Acad. Sci. USA / PubMed:31387976
MethodsX-ray diffraction
Resolution2.05 - 2.13 Å
Structure data

PDB-6nfu:
Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-6nfv:
Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

PDB-6pa0:
Structure of the G77A mutant in Sodium Chloride
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-F09:
NONAN-1-OL

ChemComp-1EM:
(1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DGA:
DIACYL GLYCEROL

ChemComp-NA:
Unknown entry

Source
  • mus musculus (house mouse)
  • streptomyces lividans (bacteria)
Keywordsmembrane protein / metal transport / ion channel / membrane transport / potassium channel / protein transport/immune system / KcsA / selectivity / permeation / PROTEIN TRANSPORT / protein transport-immune system complex

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