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Structure paper

TitleMechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Journal, issue, pagesBiochemistry, Vol. 58, Page 3669-3682, Year 2019
Publish dateJan 30, 2019 (structure data deposition date)
AuthorsSrivastava, D. / Nandi, S. / Dey, M.
External linksBiochemistry / PubMed:31386812
MethodsX-ray diffraction
Resolution1.6 - 2.25 Å
Structure data

PDB-6nu1:
Crystal Structure of Human PKM2 in Complex with L-cysteine
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-6nu5:
Pyruvate Kinase M2 Mutant - S437Y in Complex with L-cysteine
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6nub:
Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-CYS:
CYSTEINE

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-MG:
Unknown entry

ChemComp-OXL:
OXALATE ION

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SCN:
THIOCYANATE ION

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SER:
SERINE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PYRUVATE KINASE M2 / CYSTEINE / INHIBITION / GLYCOLYSIS / GENE REGULATION / PHOSPHOTRANSFERASE / SERINE

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