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Structure paper

TitleMolecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Journal, issue, pagesBiochemistry, Vol. 58, Page 3711-3726, Year 2019
Publish dateApr 23, 2019 (structure data deposition date)
AuthorsHenes, M. / Kosovrasti, K. / Lockbaum, G.J. / Leidner, F. / Nachum, G.S. / Nalivaika, E.A. / Bolon, D.N.A. / Kurt Yilmaz, N. / Schiffer, C.A. / Whitfield, T.W.
External linksBiochemistry / PubMed:31386353
MethodsX-ray diffraction
Resolution1.822 - 2.127 Å
Structure data

PDB-6oos:
HIV-1 Protease NL4-3 L90M Mutant in complex with darunavir
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6oot:
HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir
Method: X-RAY DIFFRACTION / Resolution: 1.822 Å

PDB-6oou:
Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir
Method: X-RAY DIFFRACTION / Resolution: 2.127 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-017:
(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE / medication, antiretroviral*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
Keywordshydrolase/hydrolase inhibitor / HIV / NL4-3 PROTEASE / DRUG RESISTANCE / PROTEASE INHIBITOR / HYDROLASE INHIBITOR COMPLEX / HYDROLASE / hydrolase-hydrolase inhibitor complex

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