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Structure paper

TitleCD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Journal, issue, pagesBMC Mol Cell Biol, Vol. 20, Page 29-29, Year 2019
Publish dateJun 20, 2019 (structure data deposition date)
AuthorsArgiriadi, M.A. / Benatuil, L. / Dubrovska, I. / Egan, D.A. / Gao, L. / Greischar, A. / Hardman, J. / Harlan, J. / Iyer, R.B. / Judge, R.A. ...Argiriadi, M.A. / Benatuil, L. / Dubrovska, I. / Egan, D.A. / Gao, L. / Greischar, A. / Hardman, J. / Harlan, J. / Iyer, R.B. / Judge, R.A. / Lake, M. / Perron, D.C. / Sadhukhan, R. / Sielaff, B. / Sousa, S. / Wang, R. / McRae, B.L.
External linksBMC Mol Cell Biol / PubMed:31382872
MethodsX-ray diffraction
Resolution1.74 - 3.13 Å
Structure data

PDB-6pe7:
Crystal Structure of ABBV-323 FAB
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-6pe8:
Crystal structure of CD40/ABBV-323 FAB complex
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

PDB-6pe9:
Crystal Structure of CD40 complexed to FAB516
Method: X-RAY DIFFRACTION / Resolution: 3.13 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD40 / FAB / complex

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