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Structure paper

TitleSmall Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis.
Journal, issue, pagesIscience, Vol. 19, Page 110-118, Year 2019
Publish dateApr 17, 2018 (structure data deposition date)
AuthorsMiles, L.A. / Hermans, S.J. / Crespi, G.A.N. / Gooi, J.H. / Doughty, L. / Nero, T.L. / Markulic, J. / Ebneth, A. / Wroblowski, B. / Oehlrich, D. ...Miles, L.A. / Hermans, S.J. / Crespi, G.A.N. / Gooi, J.H. / Doughty, L. / Nero, T.L. / Markulic, J. / Ebneth, A. / Wroblowski, B. / Oehlrich, D. / Trabanco, A.A. / Rives, M.L. / Royaux, I. / Hancock, N.C. / Parker, M.W.
External linksIscience / PubMed:31369984
MethodsX-ray diffraction
Resolution1.751 - 1.801 Å
Structure data

PDB-6d48:
Cell Surface Receptor
Method: X-RAY DIFFRACTION / Resolution: 1.776 Å

PDB-6d49:
Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

PDB-6d4a:
Cell Surface Receptor with Bound Ligand at 1.75-A Resolution
Method: X-RAY DIFFRACTION / Resolution: 1.751 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-FVP:
2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Sialic Acid Binding / Transmembrane / Receptor / Siglec

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