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Structure paper

TitleStructural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Journal, issue, pagesStructure, Vol. 27, Page 1443-1451.e6, Year 2019
Publish dateOct 16, 2018 (structure data deposition date)
AuthorsVan Agthoven, J.F. / Shams, H. / Cochran, F.V. / Alonso, J.L. / Kintzing, J.R. / Garakani, K. / Adair, B.D. / Xiong, J.P. / Mofrad, M.R.K. / Cochran, J.R. / Arnaout, M.A.
External linksStructure / PubMed:31353240
MethodsX-ray diffraction
Resolution3.104 - 3.11 Å
Structure data

PDB-6msl:
Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
Method: X-RAY DIFFRACTION / Resolution: 3.104 Å

PDB-6msu:
Integrin alphaVBeta3 in complex with EETI-II 2.5F
Method: X-RAY DIFFRACTION / Resolution: 3.11 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • ecballium elaterium (jumping cucumber)
KeywordsCELL ADHESION / HYBRID DOMAIN / PSI / EGF REPEATS / BETA TAIL / CALF / THIGH / BETA PROPELLER / RGD MOTIF / FIBRONECTIN / VITRONECTIN

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