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Structure paper

TitleDetection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes.
Journal, issue, pagesJ. Exp. Med., Vol. 216, Page 2331-2347, Year 2019
Publish dateApr 15, 2019 (structure data deposition date)
AuthorsBancroft, T. / DeBuysscher, B.L. / Weidle, C. / Schwartz, A. / Wall, A. / Gray, M.D. / Feng, J. / Steach, H.R. / Fitzpatrick, K.S. / Gewe, M.M. ...Bancroft, T. / DeBuysscher, B.L. / Weidle, C. / Schwartz, A. / Wall, A. / Gray, M.D. / Feng, J. / Steach, H.R. / Fitzpatrick, K.S. / Gewe, M.M. / Skog, P.D. / Doyle-Cooper, C. / Ota, T. / Strong, R.K. / Nemazee, D. / Pancera, M. / Stamatatos, L. / McGuire, A.T. / Taylor, J.J.
External linksJ. Exp. Med. / PubMed:31345930
MethodsX-ray diffraction
Resolution2.6 - 2.9 Å
Structure data

PDB-6ol5:
Structure of iglb12 Fab in complex with anti-idiotype ib3 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6ol6:
Structure of iglb12 scFv in complex with anti-idiotype ib2 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NH4:
AMMONIUM ION

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / glb12 / Antibody / ib3 / Fab / complex / Anti-Idiotype / HIV / Broadly Neutralizing / ib2 / Neutralizing / Broadly

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