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Structure paper

TitleStructural basis of the atypical activation mechanism of KRASV14I.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 13964-13972, Year 2019
Publish dateOct 9, 2018 (structure data deposition date)
AuthorsBera, A.K. / Lu, J. / Wales, T.E. / Gondi, S. / Gurbani, D. / Nelson, A. / Engen, J.R. / Westover, K.D.
External linksJ. Biol. Chem. / PubMed:31341022
MethodsX-ray diffraction
Resolution1.5 - 1.6 Å
Structure data

PDB-6mqg:
Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-6mqn:
Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / GTPASE KRAS HYDROLYSIS

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