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Structure paper

TitleStructural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 15505-15513, Year 2019
Publish dateAug 27, 2018 (structure data deposition date)
AuthorsGoebel, E.J. / Corpina, R.A. / Hinck, C.S. / Czepnik, M. / Castonguay, R. / Grenha, R. / Boisvert, A. / Miklossy, G. / Fullerton, P.T. / Matzuk, M.M. ...Goebel, E.J. / Corpina, R.A. / Hinck, C.S. / Czepnik, M. / Castonguay, R. / Grenha, R. / Boisvert, A. / Miklossy, G. / Fullerton, P.T. / Matzuk, M.M. / Idone, V.J. / Economides, A.N. / Kumar, R. / Hinck, A.P. / Thompson, T.B.
External linksProc. Natl. Acad. Sci. USA / PubMed:31315975
MethodsX-ray diffraction
Resolution2.34 Å
Structure data

PDB-6mac:
Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsSIGNALING PROTEIN / Growth Factor / Receptor / TGFB / Signaling

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