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TitleDiscovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 10, Page 1033-1038, Year 2019
Publish dateMay 12, 2019 (structure data deposition date)
AuthorsLin, H. / Wang, M. / Zhang, Y.W. / Tong, S. / Leal, R.A. / Shetty, R. / Vaddi, K. / Luengo, J.I.
External linksAcs Med. Chem. Lett. / PubMed:31312404
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6k1s:
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CUX:
2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PRMT5 / complex / covalent / inhibitor

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