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TitleStructural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1.
Journal, issue, pagesFebs J., Vol. 287, Page 173-189, Year 2020
Publish dateFeb 28, 2019 (structure data deposition date)
AuthorsLaciak, A.R. / Korasick, D.A. / Wyatt, J.W. / Gates, K.S. / Tanner, J.J.
External linksFebs J. / PubMed:31302938
MethodsX-ray diffraction
Resolution1.7 - 2.05 Å
Structure data

PDB-6o4b:
Structure of ALDH7A1 mutant W175G complexed with NAD
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6o4c:
Structure of ALDH7A1 mutant W175A complexed with NAD
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6o4d:
Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-6o4e:
Structure of ALDH7A1 mutant N167S complexed with NAD
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-6o4f:
Structure of ALDH7A1 mutant N167S complexed with alpha-aminoadipate
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6o4g:
Structure of ALDH7A1 mutant P169S complexed with alpha-aminoadipate
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-6o4h:
Structure of ALDH7A1 mutant A171V complexed with NAD
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-CL:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-6PC:
PYRIDINE-2-CARBOXYLIC ACID

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-UN1:
2-AMINOHEXANEDIOIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / ALDEHYDE DEHYDROGENASE / NAD / LYSINE CATABOLISM

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