タイトル | Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors. |
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ジャーナル・号・ページ | Bioorg. Med. Chem., Vol. 27, Page 3692-3706, Year 2019 |
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掲載日 | 2019年7月3日 (構造データの登録日) |
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著者 | Chino, A. / Honda, S. / Morita, M. / Yonezawa, K. / Hamaguchi, W. / Amano, Y. / Moriguchi, H. / Yamazaki, M. / Aota, M. / Tomishima, M. / Masuda, N. |
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リンク | Bioorg. Med. Chem. / PubMed:31301949 |
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手法 | X線回折 |
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解像度 | 2.44 - 3.1 Å |
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構造データ | PDB-6kdx: Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.44 Å PDB-6kdz: Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-6ke0: Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å |
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化合物 | ChemComp-D6X: N-[2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)ethyl]quinolin-2-amine
ChemComp-D79: 4-[2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)ethyl]-3,7,8,10-tetrazatricyclo[7.4.0.0^{2,7}]trideca-1,3,5,8,10,12-hexaen-6-ol
ChemComp-D7C: 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-[(2S)-2-methyl-1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl]ethanone
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / Inhibitor |
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