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Structure paper

TitleFunctional divergence caused by mutations in an energetic hotspot in ERK2.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 15514-15523, Year 2019
Publish dateMay 2, 2019 (structure data deposition date)
AuthorsTaylor 4th, C.A. / Cormier, K.W. / Keenan, S.E. / Earnest, S. / Stippec, S. / Wichaidit, C. / Juang, Y.C. / Wang, J. / Shvartsman, S.Y. / Goldsmith, E.J. / Cobb, M.H.
External linksProc. Natl. Acad. Sci. USA / PubMed:31296562
MethodsX-ray diffraction
Resolution1.65 - 2.1 Å
Structure data

PDB-6ot6:
Rat ERK2 D319N
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6ots:
Rat ERK2 E320K
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSFERASE / kinase / MAPK / ERK / sevenmaker / cancer

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