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TitleMechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 12109-12120, Year 2019
Publish dateSep 5, 2016 (structure data deposition date)
AuthorsLasorsa, A. / Nardella, M.I. / Rosato, A. / Mirabelli, V. / Caliandro, R. / Natile, G. / Arnesano, F.
External linksJ. Am. Chem. Soc. / PubMed:31283225
MethodsX-ray diffraction
Resolution2.83 Å
Structure data

PDB-5t7l:
Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

Chemicals

ChemComp-PT:
Unknown entry

ChemComp-CU:
COPPER (II) ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Atox1-MNK1 / Pt-binding / heterodimer

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