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-Structure paper
Title | Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. |
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Journal, issue, pages | Nature, Vol. 571, Page 284-288, Year 2019 |
Publish date | Feb 26, 2019 (structure data deposition date) |
![]() | Deshpande, I. / Liang, J. / Hedeen, D. / Roberts, K.J. / Zhang, Y. / Ha, B. / Latorraca, N.R. / Faust, B. / Dror, R.O. / Beachy, P.A. ...Deshpande, I. / Liang, J. / Hedeen, D. / Roberts, K.J. / Zhang, Y. / Ha, B. / Latorraca, N.R. / Faust, B. / Dror, R.O. / Beachy, P.A. / Myers, B.R. / Manglik, A. |
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Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | ![]() PDB-6o3c: |
Chemicals | ![]() ChemComp-PO4: ![]() ChemComp-NA: ![]() ChemComp-OLB: ![]() ChemComp-NAG: ![]() ChemComp-LKD: ![]() ChemComp-CLR: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / GPCR / Signaling / Hedgehog / Smoothened / Cholesterol / SAG |