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Structure paper

TitleDifficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.
Journal, issue, pagesNat Commun, Vol. 10, Page 2898-2898, Year 2019
Publish dateOct 2, 2018 (structure data deposition date)
AuthorsHan, Q. / Jones, J.A. / Nicely, N.I. / Reed, R.K. / Shen, X. / Mansouri, K. / Louder, M. / Trama, A.M. / Alam, S.M. / Edwards, R.J. ...Han, Q. / Jones, J.A. / Nicely, N.I. / Reed, R.K. / Shen, X. / Mansouri, K. / Louder, M. / Trama, A.M. / Alam, S.M. / Edwards, R.J. / Bonsignori, M. / Tomaras, G.D. / Korber, B. / Montefiori, D.C. / Mascola, J.R. / Seaman, M.S. / Haynes, B.F. / Saunders, K.O.
External linksNat Commun / PubMed:31263112
MethodsX-ray diffraction
Resolution1.804 - 2.7 Å
Structure data

PDB-6mnq:
Rhesus macaque anti-HIV V3 antibody DH727.2 with gp120 V3 ZAM18 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.804 Å

PDB-6mnr:
Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.201 Å

PDB-6mns:
Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-PO4:
PHOSPHATE ION

Source
  • macaca mulatta (Rhesus monkey)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / HIV-1 gp120 V3 antibody

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