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-Structure paper
タイトル | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. |
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ジャーナル・号・ページ | Mabs, Vol. 11, Page 1036-1052, Year 2019 |
掲載日 | 2019年1月11日 (構造データの登録日) |
![]() | Sim, J. / Sockolosky, J.T. / Sangalang, E. / Izquierdo, S. / Pedersen, D. / Harriman, W. / Wibowo, A.S. / Carter, J. / Madan, A. / Doyle, L. ...Sim, J. / Sockolosky, J.T. / Sangalang, E. / Izquierdo, S. / Pedersen, D. / Harriman, W. / Wibowo, A.S. / Carter, J. / Madan, A. / Doyle, L. / Harrabi, O. / Kauder, S.E. / Chen, A. / Kuo, T.C. / Wan, H. / Pons, J. |
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手法 | X線回折 |
解像度 | 1.83 - 2.61 Å |
構造データ | ![]() PDB-6nmr: ![]() PDB-6nms: ![]() PDB-6nmt: ![]() PDB-6nmu: ![]() PDB-6nmv: |
化合物 | ![]() ChemComp-HOH: |
由来 |
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![]() | IMMUNE SYSTEM / SIRP-alpha / Signal regulatory protein alpha / Signal-regulatory protein alpha / Tyrosine-protein phosphatase non-receptor type substrate 1 / CD47 / Cluster of Differentiation 47 / anti-SIRP-alpha antibody / Blocking anti-SIRP-alpha antibody / Non-Blocking anti-SIRP-alpha antibody / Kick-Off anti-SIRP-alpha antibody / anti-SIRP-alpha antibody in complex with SIRP-alpha |