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TitleDiscovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha.
Journal, issue, pagesMabs, Vol. 11, Page 1036-1052, Year 2019
Publish dateJan 11, 2019 (structure data deposition date)
AuthorsSim, J. / Sockolosky, J.T. / Sangalang, E. / Izquierdo, S. / Pedersen, D. / Harriman, W. / Wibowo, A.S. / Carter, J. / Madan, A. / Doyle, L. ...Sim, J. / Sockolosky, J.T. / Sangalang, E. / Izquierdo, S. / Pedersen, D. / Harriman, W. / Wibowo, A.S. / Carter, J. / Madan, A. / Doyle, L. / Harrabi, O. / Kauder, S.E. / Chen, A. / Kuo, T.C. / Wan, H. / Pons, J.
External linksMabs / PubMed:31257988
MethodsX-ray diffraction
Resolution1.83 - 2.61 Å
Structure data

PDB-6nmr:
Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-6nms:
Blocking Fab 136 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-6nmt:
Non-Blocking Fab 3 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-6nmu:
Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-6nmv:
Non-Blocking Fab 218 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / SIRP-alpha / Signal regulatory protein alpha / Signal-regulatory protein alpha / Tyrosine-protein phosphatase non-receptor type substrate 1 / CD47 / Cluster of Differentiation 47 / anti-SIRP-alpha antibody / Blocking anti-SIRP-alpha antibody / Non-Blocking anti-SIRP-alpha antibody / Kick-Off anti-SIRP-alpha antibody / anti-SIRP-alpha antibody in complex with SIRP-alpha

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