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-Structure paper
Title | Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 6734-6750, Year 2019 |
Publish date | Mar 4, 2019 (structure data deposition date) |
Authors | Wang, Q. / Arnst, K.E. / Wang, Y. / Kumar, G. / Ma, D. / White, S.W. / Miller, D.D. / Li, W. |
External links | J. Med. Chem. / PubMed:31251599 |
Methods | X-ray diffraction |
Resolution | 2.3 - 3.003 Å |
Structure data | PDB-6o5m: PDB-6o5n: PDB-6o61: |
Chemicals | ChemComp-GTP: ChemComp-CA: ChemComp-MG: ChemComp-GOL: ChemComp-GDP: ChemComp-MES: ChemComp-G8K: ChemComp-ACP: ChemComp-HOH: ChemComp-QW9: ChemComp-KUM: |
Source |
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Keywords | CELL CYCLE / Microtubule Inhibitor / Colchicine / Cancer |