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Structure paper

TitleSGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
Journal, issue, pagesJ. Cell Biol., Vol. 218, Page 2699-2725, Year 2019
Publish dateNov 1, 2018 (structure data deposition date)
AuthorsAwadia, S. / Huq, F. / Arnold, T.R. / Goicoechea, S.M. / Sun, Y.J. / Hou, T. / Kreider-Letterman, G. / Massimi, P. / Banks, L. / Fuentes, E.J. ...Awadia, S. / Huq, F. / Arnold, T.R. / Goicoechea, S.M. / Sun, Y.J. / Hou, T. / Kreider-Letterman, G. / Massimi, P. / Banks, L. / Fuentes, E.J. / Miller, A.L. / Garcia-Mata, R.
External linksJ. Cell Biol. / PubMed:31248911
MethodsX-ray diffraction
Resolution1.1 - 1.6 Å
Structure data

PDB-6mye:
Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

PDB-6myf:
Crystal structure of free human Scribble PDZ1 domain
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL ADHESION / Guanyl nucleotide exchange factor / SGEF/Scribble/Dlg1 compelx / tight junction / PEPTIDE BINDING PROTEIN / PDZ binding motif binding

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