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TitleSera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.
Journal, issue, pagesImmunity, Vol. 50, Page 1530-1541.e8, Year 2019
Publish dateNov 28, 2018 (structure data deposition date)
AuthorsLindesmith, L.C. / McDaniel, J.R. / Changela, A. / Verardi, R. / Kerr, S.A. / Costantini, V. / Brewer-Jensen, P.D. / Mallory, M.L. / Voss, W.N. / Boutz, D.R. ...Lindesmith, L.C. / McDaniel, J.R. / Changela, A. / Verardi, R. / Kerr, S.A. / Costantini, V. / Brewer-Jensen, P.D. / Mallory, M.L. / Voss, W.N. / Boutz, D.R. / Blazeck, J.J. / Ippolito, G.C. / Vinje, J. / Kwong, P.D. / Georgiou, G. / Baric, R.S.
External linksImmunity / PubMed:31216462
MethodsX-ray diffraction
Resolution2.579 - 3.1 Å
Structure data

PDB-6n81:
Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227
Method: X-RAY DIFFRACTION / Resolution: 2.579 Å

PDB-6n8d:
Crystal structure of GII.4 2002 norovirus P domain in complex with neutralizing human antibody A1431
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • norovirus hu/gii.4/farmington hills/2004/usa
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Norovirus / human antibody / complex / Fab / neutralizing

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