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-Structure paper
| Title | Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4. |
|---|---|
| Journal, issue, pages | Eur. J. Med. Chem., Vol. 178, Page 530-543, Year 2019 |
| Publish date | Aug 19, 2016 (structure data deposition date) |
 Authors | Myers, S.M. / Miller, D.C. / Molyneux, L. / Arasta, M. / Bawn, R.H. / Blackburn, T.J. / Cook, S.J. / Edwards, N. / Endicott, J.A. / Golding, B.T. ...Myers, S.M. / Miller, D.C. / Molyneux, L. / Arasta, M. / Bawn, R.H. / Blackburn, T.J. / Cook, S.J. / Edwards, N. / Endicott, J.A. / Golding, B.T. / Griffin, R.J. / Hammonds, T. / Hardcastle, I.R. / Harnor, S.J. / Heptinstall, A.B. / Lochhead, P.A. / Martin, M.P. / Martin, N.C. / Newell, D.R. / Owen, P.J. / Pang, L.C. / Reuillon, T. / Rigoreau, L.J.M. / Thomas, H.D. / Tucker, J.A. / Wang, L.Z. / Wong, A.C. / Noble, M.E.M. / Wedge, S.R. / Cano, C. |
 External links | Eur. J. Med. Chem. / PubMed:31212132 |
| Methods | X-ray diffraction |
| Resolution | 1.7 - 2.38 Å |
| Structure data |  PDB-5lrq:  PDB-5o7i: |
| Chemicals |  ChemComp-4WG:  ChemComp-HOH:  ChemComp-9N8:  ChemComp-DMS: |
| Source |
|
 Keywords | TRANSCRIPTION / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 / ERK5 / Inhibitor / TRANSFERASE / KINASE / PYRROLE |
homo sapiens (human)