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Structure paper

TitleStructural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.
Journal, issue, pagesActa Crystallogr D Struct Biol, Vol. 75, Page 554-563, Year 2019
Publish dateJan 16, 2019 (structure data deposition date)
AuthorsWang, Z. / Cheng, L. / Guo, G. / Cheng, B. / Hu, S. / Zhang, H. / Zhu, Z. / Niu, L.
External linksActa Crystallogr D Struct Biol / PubMed:31205018
MethodsX-ray diffraction
Resolution2.918 Å
Structure data

PDB-6j71:
HuA21-scFv in complex with the extracellular domain(ECD) of HER2
Method: X-RAY DIFFRACTION / Resolution: 2.918 Å

Chemicals

ChemComp-BMA:
beta-D-mannopyranose

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Tyrosine-protein kinase / antibody / Transcription regulation

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