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TitleExploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.
Journal, issue, pagesEur. J. Med. Chem., Vol. 178, Page 380-389, Year 2019
Publish dateMar 7, 2019 (structure data deposition date)
AuthorsIelo, L. / Deri, B. / Germano, M.P. / Vittorio, S. / Mirabile, S. / Gitto, R. / Rapisarda, A. / Ronsisvalle, S. / Floris, S. / Pazy, Y. ...Ielo, L. / Deri, B. / Germano, M.P. / Vittorio, S. / Mirabile, S. / Gitto, R. / Rapisarda, A. / Ronsisvalle, S. / Floris, S. / Pazy, Y. / Fais, A. / Fishman, A. / De Luca, L.
External linksEur. J. Med. Chem. / PubMed:31202126
MethodsX-ray diffraction
Resolution2.317 Å
Structure data

PDB-6qxd:
Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.
Method: X-RAY DIFFRACTION / Resolution: 2.317 Å

Chemicals

ChemComp-CU:
COPPER (II) ION

ChemComp-JKB:
(2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone

ChemComp-HOH:
WATER

Source
  • bacillus megaterium (bacteria)
KeywordsOXIDOREDUCTASE / Tyrosinase / Inhibitor / Ligand

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