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Structure paper

TitleStructural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Journal, issue, pagesNat Commun, Vol. 10, Page 2452-2452, Year 2019
Publish dateApr 6, 2019 (structure data deposition date)
AuthorsLong, T. / Hassan, A. / Thompson, B.M. / McDonald, J.G. / Wang, J. / Li, X.
External linksNat Commun / PubMed:31165728
MethodsX-ray diffraction
Resolution3.2 - 3.526 Å
Structure data

PDB-6oht:
Structure of EBP and U18666A
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6ohu:
Structure of EBP and tamoxifen
Method: X-RAY DIFFRACTION / Resolution: 3.526 Å

Chemicals

ChemComp-MKM:
3beta-(2-Diethylaminoethoxy)androst-5-en-17-one

ChemComp-CTX:
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE

Source
  • homo sapiens (human)
KeywordsMembrane protein / isomerase/inhibitor / Isomerase / isomerase-inhibitor complex

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