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Structure paper

TitleGenome-wide survey and crystallographic analysis suggests a role for both horizontal gene transfer and duplication in pantothenate biosynthesis pathways.
Journal, issue, pagesBiochim Biophys Acta Gen Subj, Vol. 1863, Page 1547-1559, Year 2019
Publish dateMar 16, 2018 (structure data deposition date)
AuthorsKhanppnavar, B. / Chatterjee, R. / Choudhury, G.B. / Datta, S.
External linksBiochim Biophys Acta Gen Subj / PubMed:31136784
MethodsX-ray diffraction
Resolution2.45 - 2.57 Å
Structure data

PDB-5zik:
Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-5zix:
Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa bound to NADP+
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • pseudomonas aeruginosa pao1 (bacteria)
KeywordsOXIDOREDUCTASE / 2-dehydropantoate 2-reductase / panthothenate biosythesis pathway / ApbA family / Rossman fold / NADP+ / NADPH

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