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TitleHIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Journal, issue, pagesElife, Vol. 8, Year 2019
Publish dateFeb 1, 2019 (structure data deposition date)
AuthorsKoneru, P.C. / Francis, A.C. / Deng, N. / Rebensburg, S.V. / Hoyte, A.C. / Lindenberger, J. / Adu-Ampratwum, D. / Larue, R.C. / Wempe, M.F. / Engelman, A.N. ...Koneru, P.C. / Francis, A.C. / Deng, N. / Rebensburg, S.V. / Hoyte, A.C. / Lindenberger, J. / Adu-Ampratwum, D. / Larue, R.C. / Wempe, M.F. / Engelman, A.N. / Lyumkis, D. / Fuchs, J.R. / Levy, R.M. / Melikyan, G.B. / Kvaratskhelia, M.
External linksElife / PubMed:31120420
MethodsX-ray diffraction
Resolution2.10002700303 Å
Structure data

PDB-6nuj:
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436
Method: X-RAY DIFFRACTION / Resolution: 2.10002700303 Å

Chemicals

ChemComp-L3D:
(2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / HIV / Integrase / inhibitor / allosteric / TRANSFERASE-TRANSFERASE INHIBITOR complex

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