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Structure paper

TitleStructural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 10428-10437, Year 2019
Publish dateDec 17, 2018 (structure data deposition date)
AuthorsTerzyan, S.S. / Shen, T. / Liu, X. / Huang, Q. / Teng, P. / Zhou, M. / Hilberg, F. / Cai, J. / Mooers, B.H.M. / Wu, J.
External linksJ. Biol. Chem. / PubMed:31118272
MethodsX-ray diffraction
Resolution1.87 - 1.99 Å
Structure data

PDB-6ne7:
Structure of G810A mutant of RET protein tyrosine kinase domain.
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-6nec:
STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-6nja:
Structure of WT RET protein tyrosine kinase domain at 1.92A resolution.
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-HOH:
WATER

ChemComp-XIN:
methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate / medication*YM

ChemComp-ADE:
ADENINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / oncogene / RET / Tyrosine Kinase / ATP-binding / Thyroid cancer / Non-small cell lung cancer / Nintedanib / complex

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