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TitleCrystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).
Journal, issue, pagesArch. Biochem. Biophys., Vol. 671, Page 1-7, Year 2019
Publish dateJun 21, 2018 (structure data deposition date)
AuthorsRembacz, K.P. / Zrubek, K.M. / Golik, P. / Michalik, K. / Bogusz, J. / Wladyka, B. / Romanowska, M. / Dubin, G.
External linksArch. Biochem. Biophys. / PubMed:31108049
MethodsX-ray diffraction
Resolution2.24 Å
Structure data

PDB-6gvx:
Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-TAK:
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / dorsomorphin / MELK / inhibitor / cancer

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