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Structure paper

TitleStructural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
Journal, issue, pagesNucleic Acids Res., Vol. 47, Page 8375-8387, Year 2019
Publish dateMar 25, 2019 (structure data deposition date)
AuthorsYang, J. / Horton, J.R. / Li, J. / Huang, Y. / Zhang, X. / Blumenthal, R.M. / Cheng, X.
External linksNucleic Acids Res. / PubMed:31081034
MethodsX-ray diffraction
Resolution1.494 - 2.05 Å
Structure data

PDB-6od3:
Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence
Method: X-RAY DIFFRACTION / Resolution: 1.494 Å

PDB-6od4:
Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence
Method: X-RAY DIFFRACTION / Resolution: 1.699 Å

PDB-6od5:
Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/DNA / protein-DNA complex / transcription factor / bHTH / E-Box / TRANSCRIPTION-DNA complex

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