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Structure paper

TitleDestabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 10968-10977, Year 2019
Publish dateDec 14, 2018 (structure data deposition date)
AuthorsAshraf, U. / Tengo, L. / Le Corre, L. / Fournier, G. / Busca, P. / McCarthy, A.A. / Rameix-Welti, M.A. / Gravier-Pelletier, C. / Ruigrok, R.W.H. / Jacob, Y. ...Ashraf, U. / Tengo, L. / Le Corre, L. / Fournier, G. / Busca, P. / McCarthy, A.A. / Rameix-Welti, M.A. / Gravier-Pelletier, C. / Ruigrok, R.W.H. / Jacob, Y. / Vidalain, P.O. / Pietrancosta, N. / Crepin, T. / Naffakh, N.
External linksProc. Natl. Acad. Sci. USA / PubMed:31076555
MethodsX-ray diffraction
Resolution1.8 - 3.17 Å
Structure data

PDB-6q8f:
Nterminal domain of human SMU1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6q8i:
Nterminal domain of human SMU1 in complex with human REDmid
Method: X-RAY DIFFRACTION / Resolution: 3.17 Å

PDB-6q8j:
Nterminal domain of human SMU1 in complex with LSP641
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-XS4:
1-~{tert}-butyl-3-[6-(3,5-dimethoxyphenyl)-2-[[1-[1-(phenylmethyl)piperidin-4-yl]-1,2,3-triazol-4-yl]methylamino]pyrido[2,3-d]pyrimidin-7-yl]urea

Source
  • homo sapiens (human)
KeywordsSPLICING / Splicing factor / minimal RED-SMU1 complex / influenza virus

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