タイトル | Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4. |
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ジャーナル・号・ページ | Nucleic Acids Res., Vol. 47, Page 5973-5987, Year 2019 |
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掲載日 | 2019年3月8日 (構造データの登録日) |
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著者 | Reolon, L.W. / Vichier-Guerre, S. / de Matos, B.M. / Dugue, L. / Assuncao, T.R.D.S. / Zanchin, N.I.T. / Pochet, S. / Guimaraes, B.G. |
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リンク | Nucleic Acids Res. / PubMed:31066441 |
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手法 | X線回折 |
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解像度 | 2.1 - 2.7 Å |
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構造データ | PDB-6o7y: Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-4 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6o7z: Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-1 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6o80: Trypanosoma cruzi EIF4E5 translation initiation factor in complex with m7GTP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-LRM: 2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
ChemComp-LRP: 2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(S)-{[(R)-({(2R,3R,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-3-hydroxy-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
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由来 | - trypanosoma cruzi (トリパノソーマ)
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キーワード | RNA BINDING PROTEIN / Translation Initiation Factor / trypanosomatids / cap-4 |
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