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Structure paper

TitleStudies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.
Journal, issue, pagesMedchemcomm, Vol. 10, Page 500-504, Year 2019
Publish dateJan 13, 2019 (structure data deposition date)
AuthorsHolt-Martyn, J.P. / Tumber, A. / Rahman, M.Z. / Lippl, K. / Figg Jr., W. / McDonough, M.A. / Chowdhury, R. / Schofield, C.J.
External linksMedchemcomm / PubMed:31057728
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-6qgv:
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-J2H:
8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / NON-HEME DIOXYGENASE / IRON / 2-OXOGLUTARATE / HYPOXIA-INDUCIBLE FACTOR / HIF / HIF PROLYL HYDROXYLASE DOMAIN 2 / PHD2 / EGLN1 / OXYGENASE / HYPOXIA / DNA-BINDING / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / CYTOPLASM / TRANSCRIPTION/EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / UBL CONJUGATION / POLYMORPHISM / VITAMIN C / ZINC-FINGER / FAMILIAL ERYTHROCYTOSIS / BREAST CANCER / TRANSCRIPTION COMPLEX

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