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Structure paper

TitleStructural insights into the mechanism of single domain VHH antibody binding to cortisol.
Journal, issue, pagesFebs Lett., Vol. 593, Page 1248-1256, Year 2019
Publish dateNov 24, 2018 (structure data deposition date)
AuthorsDing, L. / Wang, Z. / Zhong, P. / Jiang, H. / Zhao, Z. / Zhang, Y. / Ren, Z. / Ding, Y.
External linksFebs Lett. / PubMed:31049949
MethodsX-ray diffraction
Resolution1.526 - 1.572 Å
Structure data

PDB-6itp:
Crystal structure of cortisol complexed with its nanobody at pH 3.5
Method: X-RAY DIFFRACTION / Resolution: 1.572 Å

PDB-6itq:
Crystal structure of cortisol complexed with its nanobody at pH 10.5
Method: X-RAY DIFFRACTION / Resolution: 1.526 Å

Chemicals

ChemComp-HCY:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione / medication, hormone*YM

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • camelus bactrianus (Bactrian camel)
KeywordsIMMUNE SYSTEM / Cortisol / Complex / Nanobody / Camelid antibody

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