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Structure paper

TitleA BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Journal, issue, pagesSci Transl Med, Vol. 11, Year 2019
Publish dateApr 18, 2019 (structure data deposition date)
AuthorsSeeherman, H.J. / Berasi, S.P. / Brown, C.T. / Martinez, R.X. / Juo, Z.S. / Jelinsky, S. / Cain, M.J. / Grode, J. / Tumelty, K.E. / Bohner, M. ...Seeherman, H.J. / Berasi, S.P. / Brown, C.T. / Martinez, R.X. / Juo, Z.S. / Jelinsky, S. / Cain, M.J. / Grode, J. / Tumelty, K.E. / Bohner, M. / Grinberg, O. / Orr, N. / Shoseyov, O. / Eyckmans, J. / Chen, C. / Morales, P.R. / Wilson, C.G. / Vanderploeg, E.J. / Wozney, J.M.
External linksSci Transl Med / PubMed:31019025
MethodsX-ray diffraction
Resolution2.68 - 2.8 Å
Structure data

PDB-6oml:
Human BMP chimera BV261
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6omn:
Glycosylated BMP2 homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

PDB-6omo:
Human BMP6 homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / BMP / bone morphogenetic protein / Bone Mophogenetic Protein

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