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-Structure paper
Title | Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 4401-4410, Year 2019 |
Publish date | Nov 26, 2018 (structure data deposition date) |
Authors | Riggs, J.R. / Elsner, J. / Cashion, D. / Robinson, D. / Tehrani, L. / Nagy, M. / Fultz, K.E. / Krishna Narla, R. / Peng, X. / Tran, T. ...Riggs, J.R. / Elsner, J. / Cashion, D. / Robinson, D. / Tehrani, L. / Nagy, M. / Fultz, K.E. / Krishna Narla, R. / Peng, X. / Tran, T. / Kulkarni, A. / Bahmanyar, S. / Condroski, K. / Pagarigan, B. / Fenalti, G. / LeBrun, L. / Leftheris, K. / Zhu, D. / Boylan, J.F. |
External links | J. Med. Chem. / PubMed:30998356 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-6n6o: |
Chemicals | ChemComp-KE7: ChemComp-1PE: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | SIGNALING PROTEIN / Protein Kinase Activity Protein Serine/Threonine/Tyrosine kinase activity ATP Binding Protein Phosphorylation Mitotic Cell Cycle Checkpoint Chromosome Separation |