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Structure paper

TitleStructural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Journal, issue, pagesNucleic Acids Res., Vol. 47, Page 5712-5722, Year 2019
Publish dateJul 12, 2018 (structure data deposition date)
AuthorsTer Beek, J. / Parkash, V. / Bylund, G.O. / Osterman, P. / Sauer-Eriksson, A.E. / Johansson, E.
External linksNucleic Acids Res. / PubMed:30968138
MethodsX-ray diffraction
Resolution2.7 - 2.8 Å
Structure data

PDB-6h1v:
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6qib:
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • synthetic construct (others)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsDNA BINDING PROTEIN / Pol epsilon / M644G / DNA / complex / Fe-S / P-domain

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