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-Structure paper
Title | Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 4716-4730, Year 2019 |
Publish date | Dec 28, 2018 (structure data deposition date) |
![]() | Zhang, Y. / Wu, X. / Xue, X. / Li, C. / Wang, J. / Wang, R. / Zhang, C. / Wang, C. / Shi, Y. / Zou, L. ...Zhang, Y. / Wu, X. / Xue, X. / Li, C. / Wang, J. / Wang, R. / Zhang, C. / Wang, C. / Shi, Y. / Zou, L. / Li, Q. / Huang, Z. / Hao, X. / Loomes, K. / Wu, D. / Chen, H.W. / Xu, J. / Xu, Y. |
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Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-6j1l: |
Chemicals | ![]() ChemComp-B6L: ![]() ChemComp-HOH: |
Source |
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![]() | DNA BINDING PROTEIN / ROR gamma / LBD / Inhibitor |