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Structure paper

TitleHow C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Journal, issue, pagesSci Immunol, Vol. 4, Year 2019
Publish dateMay 15, 2018 (structure data deposition date)
AuthorsWang, Y. / Sosinowski, T. / Novikov, A. / Crawford, F. / White, J. / Jin, N. / Liu, Z. / Zou, J. / Neau, D. / Davidson, H.W. ...Wang, Y. / Sosinowski, T. / Novikov, A. / Crawford, F. / White, J. / Jin, N. / Liu, Z. / Zou, J. / Neau, D. / Davidson, H.W. / Nakayama, M. / Kwok, W.W. / Gapin, L. / Marrack, P. / Kappler, J.W. / Dai, S.
External linksSci Immunol / PubMed:30952805
MethodsX-ray diffraction
Resolution1.71 - 3.2 Å
Structure data

PDB-6dfq:
mouse diabetogenic TCR I.29
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-6dfs:
mouse TCR I.29 in complex with IAg7-p8E9E6ss
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-6dfv:
Mouse diabetogenic TCR 8F10
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-6dfw:
TCR 8F10 in complex with IAg7-p8G9E
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6dfx:
human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T cell receptor / Type 1 Diabetes / Autoimmunity

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