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TitleTissue-Specific Oncogenic Activity of KRASA146T.
Journal, issue, pagesCancer Discov, Vol. 9, Page 738-755, Year 2019
Publish dateNov 20, 2017 (structure data deposition date)
AuthorsPoulin, E.J. / Bera, A.K. / Lu, J. / Lin, Y.J. / Strasser, S.D. / Paulo, J.A. / Huang, T.Q. / Morales, C. / Yan, W. / Cook, J. ...Poulin, E.J. / Bera, A.K. / Lu, J. / Lin, Y.J. / Strasser, S.D. / Paulo, J.A. / Huang, T.Q. / Morales, C. / Yan, W. / Cook, J. / Nowak, J.A. / Brubaker, D.K. / Joughin, B.A. / Johnson, C.W. / DeStefanis, R.A. / Ghazi, P.C. / Gondi, S. / Wales, T.E. / Iacob, R.E. / Bogdanova, L. / Gierut, J.J. / Li, Y. / Engen, J.R. / Perez-Mancera, P.A. / Braun, B.S. / Gygi, S.P. / Lauffenburger, D.A. / Westover, K.D. / Haigis, K.M.
External linksCancer Discov / PubMed:30952657
MethodsX-ray diffraction
Resolution1.401 Å
Structure data

PDB-6bof:
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
Method: X-RAY DIFFRACTION / Resolution: 1.401 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / small gtpase / signal transduction / GDP binding

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