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Structure paper

TitleThe FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Journal, issue, pagesIscience, Vol. 14, Page 113-124, Year 2019
Publish dateDec 27, 2018 (structure data deposition date)
AuthorsChen, D. / Tan, S. / Zhang, H. / Wang, H. / He, W. / Shi, R. / Tong, Z. / Zhu, J. / Cheng, H. / Gao, S. ...Chen, D. / Tan, S. / Zhang, H. / Wang, H. / He, W. / Shi, R. / Tong, Z. / Zhu, J. / Cheng, H. / Gao, S. / Chai, Y. / Qi, J. / Xiao, M. / Yan, J. / Gao, G.F.
External linksIscience / PubMed:30952089
MethodsX-ray diffraction
Resolution1.4 - 2.6 Å
Structure data

PDB-6j14:
Complex structure of GY-14 and PD-1
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-6j15:
Complex structure of GY-5 Fab and PD-1
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / tumor immunotherapy / complex structure / FG loop

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