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TitleDiscovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 4218-4224, Year 2019
Publish dateJun 15, 2018 (structure data deposition date)
AuthorsWu, Y. / Zhou, Q. / Zhang, T. / Li, Z. / Chen, Y.P. / Zhang, P. / Yu, Y.F. / Geng, H. / Tian, Y.J. / Zhang, C. ...Wu, Y. / Zhou, Q. / Zhang, T. / Li, Z. / Chen, Y.P. / Zhang, P. / Yu, Y.F. / Geng, H. / Tian, Y.J. / Zhang, C. / Wang, Y. / Chen, J.W. / Chen, Y. / Luo, H.B.
External linksJ. Med. Chem. / PubMed:30916555
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6a3n:
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-9Q9:
1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE9 inhibitor complex

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