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-Structure paper
Title | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 116, Page 6812-6817, Year 2019 |
Publish date | Feb 26, 2019 (structure data deposition date) |
Authors | Raman, S. / Beilschmidt, M. / To, M. / Lin, K. / Lui, F. / Jmeian, Y. / Ng, M. / Fernandez, M. / Fu, Y. / Mascall, K. ...Raman, S. / Beilschmidt, M. / To, M. / Lin, K. / Lui, F. / Jmeian, Y. / Ng, M. / Fernandez, M. / Fu, Y. / Mascall, K. / Duque, A. / Wang, X. / Pan, G. / Angers, S. / Moffat, J. / Sidhu, S.S. / Magram, J. / Sinclair, A.M. / Fransson, J. / Julien, J.P. |
External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:30894493 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.5 Å |
Structure data | PDB-6o39: PDB-6o3a: PDB-6o3b: |
Chemicals | ChemComp-EDO: ChemComp-ACT: ChemComp-NAG: ChemComp-HOH: ChemComp-CXS: ChemComp-NA: ChemComp-GOL: |
Source |
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Keywords | SIGNALING PROTEIN / Receptor / Wnt / Frizzled / CRD / Antibody |