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| Title | Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 62, Page 3228-3250, Year 2019 |
| Publish date | Mar 11, 2019 (structure data deposition date) |
 Authors | Watterson, S.H. / Liu, Q. / Beaudoin Bertrand, M. / Batt, D.G. / Li, L. / Pattoli, M.A. / Skala, S. / Cheng, L. / Obermeier, M.T. / Moore, R. ...Watterson, S.H. / Liu, Q. / Beaudoin Bertrand, M. / Batt, D.G. / Li, L. / Pattoli, M.A. / Skala, S. / Cheng, L. / Obermeier, M.T. / Moore, R. / Yang, Z. / Vickery, R. / Elzinga, P.A. / Discenza, L. / D'Arienzo, C. / Gillooly, K.M. / Taylor, T.L. / Pulicicchio, C. / Zhang, Y. / Heimrich, E. / McIntyre, K.W. / Ruan, Q. / Westhouse, R.A. / Catlett, I.M. / Zheng, N. / Chaudhry, C. / Dai, J. / Galella, M.A. / Tebben, A.J. / Pokross, M. / Li, J. / Zhao, R. / Smith, D. / Rampulla, R. / Allentoff, A. / Wallace, M.A. / Mathur, A. / Salter-Cid, L. / Macor, J.E. / Carter, P.H. / Fura, A. / Burke, J.R. / Tino, J.A. |
 External links | J. Med. Chem. / PubMed:30893553 |
| Methods | X-ray diffraction |
| Resolution | 1.42 Å |
| Structure data |  PDB-6o8i: |
| Chemicals |  ChemComp-LTJ:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE/INHIBITOR / PROTEIN KINASE / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)