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TitleGlycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Journal, issue, pagesMabs, Vol. 11, Page 681-690, Year 2019
Publish dateJan 26, 2019 (structure data deposition date)
AuthorsLiu, H. / Guo, L. / Zhang, J. / Zhou, Y. / Zhou, J. / Yao, J. / Wu, H. / Yao, S. / Chen, B. / Chai, Y. ...Liu, H. / Guo, L. / Zhang, J. / Zhou, Y. / Zhou, J. / Yao, J. / Wu, H. / Yao, S. / Chen, B. / Chai, Y. / Qi, J. / Gao, G.F. / Tan, S. / Feng, H. / Yan, J.
External linksMabs / PubMed:30892132
MethodsX-ray diffraction
Resolution2.47 Å
Structure data

PDB-6jbt:
Complex structure of toripalimab-Fab and PD-1
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / toripalimab-Fab / PD-1 / glycosylation / complex structure

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