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Structure paper

TitleCrystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 10, Page 243-247, Year 2019
Publish dateAug 14, 2018 (structure data deposition date)
AuthorsLaulumaa, S. / Hansen, K.V. / Masternak, M. / Drapier, T. / Francotte, P. / Pirotte, B. / Frydenvang, K. / Kastrup, J.S.
External linksAcs Med. Chem. Lett. / PubMed:30891120
MethodsX-ray diffraction
Resolution1.6 - 2.4 Å
Structure data

PDB-6hc9:
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 2.4 A RESOLUTION.
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6hca:
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION
Method: X-RAY DIFFRACTION / Resolution: 1.882 Å

PDB-6hcb:
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION.
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6hcc:
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.
Method: X-RAY DIFFRACTION / Resolution: 1.617 Å

PDB-6hch:
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-FXW:
6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE)

ChemComp-HOH:
WATER

ChemComp-D45:
6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide)

ChemComp-ACT:
ACETATE ION

ChemComp-ZN:
Unknown entry

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / ampa receptor / gluA2 / ligand-binding domain / glua2-S1S2J-L504Y-N775S / signaling protein / positive allosteric modulator / GluA2-S1S2J / glua2-S1S2J-N775S

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