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TitleLongitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.
Journal, issue, pagesImmunity, Vol. 50, Page 677-691.e13, Year 2019
Publish dateOct 21, 2018 (structure data deposition date)
AuthorsKrebs, S.J. / Kwon, Y.D. / Schramm, C.A. / Law, W.H. / Donofrio, G. / Zhou, K.H. / Gift, S. / Dussupt, V. / Georgiev, I.S. / Schatzle, S. ...Krebs, S.J. / Kwon, Y.D. / Schramm, C.A. / Law, W.H. / Donofrio, G. / Zhou, K.H. / Gift, S. / Dussupt, V. / Georgiev, I.S. / Schatzle, S. / McDaniel, J.R. / Lai, Y.T. / Sastry, M. / Zhang, B. / Jarosinski, M.C. / Ransier, A. / Chenine, A.L. / Asokan, M. / Bailer, R.T. / Bose, M. / Cagigi, A. / Cale, E.M. / Chuang, G.Y. / Darko, S. / Driscoll, J.I. / Druz, A. / Gorman, J. / Laboune, F. / Louder, M.K. / McKee, K. / Mendez, L. / Moody, M.A. / O'Sullivan, A.M. / Owen, C. / Peng, D. / Rawi, R. / Sanders-Buell, E. / Shen, C.H. / Shiakolas, A.R. / Stephens, T. / Tsybovsky, Y. / Tucker, C. / Verardi, R. / Wang, K. / Zhou, J. / Zhou, T. / Georgiou, G. / Alam, S.M. / Haynes, B.F. / Rolland, M. / Matyas, G.R. / Polonis, V.R. / McDermott, A.B. / Douek, D.C. / Shapiro, L. / Tovanabutra, S. / Michael, N.L. / Mascola, J.R. / Robb, M.L. / Kwong, P.D. / Doria-Rose, N.A.
External linksImmunity / PubMed:30876875
MethodsX-ray diffraction
Resolution1.7 - 2.7 Å
Structure data

PDB-6mto:
Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold
Method: X-RAY DIFFRACTION / Resolution: 2.634 Å

PDB-6mtp:
Crystal structure of VRC42.04 Fab in complex with gp41 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.036 Å

PDB-6mtq:
Crystal structure of VRC42.N1 Fab in complex with T117-F MPER scaffold
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6mtr:
Crystal structure of VRC43.01 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.798 Å

PDB-6mts:
Crystal structure of VRC43.03 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.437 Å

PDB-6mtt:
Crystal structure of VRC46.01 Fab in complex with gp41 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / Anti-HIV-1 human antibody / MPER / gp41

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